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Phenotypes Associated with This Genotype
Genotype
MGI:5141145
Allelic
Composition		 Tet2tm1.1Iaai/Tet2+
Tg(VAV1-cre)1Graf/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet2tm1.1Iaai mutation (2 available); any Tet2 mutation (778 available)
Tg(VAV1-cre)1Graf mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased leukocyte cell number ( J:174053 )
• progressive in the peripheral blood
increased monocyte cell number ( J:174053 )
• in the peripheral blood
abnormal hematopoietic stem cell physiology ( J:174053 )
• hematopoietic progenitors exhibit increased serial replating capacity compared with control cells

immune system
increased leukocyte cell number ( J:174053 )
• progressive in the peripheral blood
increased monocyte cell number ( J:174053 )
• in the peripheral blood

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory