Phenotypes for Ighm Unc93b1 MGI:5140974 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ighm^tm1Cgn/Ighm^tm1Cgn Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Cgn mutation (18 available); any Ighm mutation (57 available)
Unc93b1^tm1.1Kmiy mutation (6 available); any Unc93b1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:174308 )

N	• unlike Unc93b1^tm1.1Kmiy homozygotes, mice do not exhibit premature death

hematopoietic system

hematopoietic system phenotype ( J:174308 )

N	• unlike in Unc93b1^tm1.1Kmiy homozygotes, spleen size is normal • unlike in Unc93b1^tm1.1Kmiy homozygotes, mice do not exhibit differentiation towards memory CD4+ T cells

thrombocytopenia ( J:174308 )

• not as severe as in Unc93b1^tm1.1Kmiy homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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