Phenotypes for Igh MGI:5140411 MGI Mouse

immune system phenotype ( J:174233 )

N	• VDJ-recombination is normal

abnormal B cell morphology ( J:174233 )

• BAFF-treated B cells exhibit less of an increase in cell size than wild-type mice

abnormal B cell differentiation ( J:174233 )

• bone marrow B cell development is partially blocked at the pro-B to pre-B, the pre-B to immature B, and the immature B to mature B-cell stages compared to in wild-type mice

abnormal B cell number ( J:174233 )

• mice exhibit an increase in the ratios of pre-B to immature B cells and immature B cells to mature B cells compared to in wild-type mice

• the ratio of follicular to marginal zone B cells is decreased compared to in wild-type mice

decreased B cell number ( J:174233 )

• in bone marrow lymphocyte population

decreased immature B cell number ( J:174233 )

decreased transitional stage T2 B cell number ( J:174233 )

• slightly

decreased mature B cell number ( J:174233 )

decreased B-1a cell number ( J:174233 )

• severely in the peritoneum

decreased follicular B cell number ( J:174233 )

• severe

absent plasma cells ( J:174233 )

• extrafollicular IgM-secreting plasma cells (IgMhigh) are almost completely absent in splenic sections unlike in wild-type mice

abnormal marginal zone B cell morphology ( J:174233 )

• mice exhibit a relative increase in marginal zone (MZ) B cell without an increase in the absolute number of MZ B cells

decreased IgG level ( J:174233 )

• 3-fold in unstimulated mice

decreased IgG3 level ( J:174233 )

• 10-fold in response to trinitrophenol (TNP) stimulation after 8 days

decreased IgM level ( J:174233 )

• 10-fold in unstimulated mice

• 100-fold in response to trinitrophenol (TNP) stimulation after 8 days

• in LPS-stimulated B cells

abnormal marginal zone B cell physiology ( J:174233 )

• upon BCR stimulation, marginal zone B cells exhibit lower sustained calcium release compared with wild-type cells