Phenotypes Associated with This Genotype

Genotype
MGI:5140210

• Allelic Composition: Tg(TG-TSHR)51.9Smcl/?
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:118100 )

N • mice do not produce antibodies to the thyroid receptor in response to low dose immunization with A-subunit adenovirus

N • high dose administration of adenovirus produces some antibody response in some transgenic animals

N • T cells do not respond to challenge with purified A-subunit protein

N • mice have normal thyroid architecture and normal levels of thyroxine (T4)