Phenotypes Associated with This Genotype

Genotype
MGI:5056146

• Allelic Composition: Kdm4a^tm1Zpl/Kdm4a^tm1Zpl; Tg(Myh6-cre)1Jmk/0
• Genetic Background: involves: 129S6/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Kdm4a^tm1Zpl/Kdm4a^tm1Zpl Tg(Myh6-cre)1Jmk/0 mice exhibit abnormal heart phenotypes following transverse aortic constriction

cardiovascular system

cardiovascular system phenotype ( J:173908 )

N • mice exhibit normal baseline cardiac phenotype

decreased myocardial fiber size ( J:173908 )

• following transverse aortic constriction

decreased heart weight ( J:173908 )

• following transverse aortic constriction

abnormal heart left ventricle morphology ( J:173908 )

• following transverse aortic constriction, mice exhibit decreased left ventricular internal dimension in systole compared with wild-type mice

increased cardiac muscle contractility ( J:173908 )

• following transverse aortic constriction

decreased response of heart to induced stress ( J:173908 )

• following transverse aortic constriction, mice exhibit a smaller increase in heart weight to body weight and cross-sectional cardiomyocyte areas and improved cardiac function compared with similarly treated wild-type mice

homeostasis/metabolism

decreased response of heart to induced stress ( J:173908 )

• following transverse aortic constriction, mice exhibit a smaller increase in heart weight to body weight and cross-sectional cardiomyocyte areas and improved cardiac function compared with similarly treated wild-type mice

muscle

decreased myocardial fiber size ( J:173908 )

• following transverse aortic constriction

increased cardiac muscle contractility ( J:173908 )

• following transverse aortic constriction