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Phenotypes Associated with This Genotype
Genotype
MGI:5056093
Allelic
Composition
Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic
Background
C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smoc1tm1a(EUCOMM)Wtsi mutation (2 available); any Smoc1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ophthalmo-acromelic-like phenotype in Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi mice

mortality/aging
• all mice die at or soon after birth

vision/eye
• reduced diameter
• the retinal pigmented epithelium extends into the optic nerve unlike in wild-type mice
• in 56% of mice
• in 56% of mice

limbs/digits/tail
• osseous syndactyly

growth/size/body
• in 4 of 12 mice
• in neonates

craniofacial
• in 4 of 12 mice

nervous system
• reduced diameter

digestive/alimentary system
• in 4 of 12 mice

embryo

skeleton

pigmentation
• the retinal pigmented epithelium extends into the optic nerve unlike in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Microphthalmia with Limb Anomalies; MLA 206920 J:174198


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory