Mouse Genome Informatics
hm
    Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Ophthalmo-acromelic-like phenotype in Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi mice

mortality/aging
• all mice die at or soon after birth

vision/eye
• reduced diameter
• the retinal pigmented epithelium extends into the optic nerve unlike in wild-type mice
• in 56% of mice
• in 56% of mice

limbs/digits/tail
• osseous syndactyly

growth/size
• in neonates

craniofacial
• in 4 of 12 mice

nervous system
• reduced diameter

digestive/alimentary system
• in 4 of 12 mice

embryogenesis

skeleton

pigmentation
• the retinal pigmented epithelium extends into the optic nerve unlike in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Microphthalmia with Limb Anomalies 206920 J:174198