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Phenotypes Associated with This Genotype
Genotype
MGI:5052332
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Kiss1rtm1.1(cre)Uboe/Kiss1r+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Kiss1rtm1.1(cre)Uboe mutation (0 available); any Kiss1r mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:173936 )
N
• female mice exhibit normal onset of puberty, ovalutory cyclicity, and fertile
abnormal vagina development ( J:173936 )
• female mice exhibit slightly prolonged phases of cornification compared with wild-type mice

nervous system
decreased neuron number ( J:173936 )
• the number of gonadotrophin-releasing hormone neurons in the hypothalamus of female mice is decreased compared to in wild-type mice

endocrine/exocrine glands

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory