Analysis Tools
hematopoietic system
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• mice exhibit normal response to 5-FU treatment
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• spontaneous or dexamethasome-induced
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• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice
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• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice
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• Ter-119+ cells exhibit decreased apoptosis compared to in wild-type mice
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• Gr-1+ cells exhibit a reduced rate of spontaneous and G-CSF deprivation-induced apoptosis compared with wild-type cells
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• aged mice exhibit enhanced myelopoiesis develop neutrophilia unlike wild-type mice
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• mice exhibit a 1.5-fold increase in bone marrow cell compared with wild-type mice
• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice
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• mice exhibit increased Ter-119+ and burst forming unit erythroid cells in the peripheral blood, bone marrow, and spleen compared with wild-type mice
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• 3-fold
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• in adult and aged mice
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• mice exhibit a 1.96-fold increase in white blood cell compared with wild-type mice
• the increase in white blood cell is severe in wild-type mice transplanted with bone marrow from homozygous mice
• at 18 months, mice exhibit increased white blood cells compared with wild-type mice
• however, the number of basophils is normal
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• in wild-type mice transplanted with bone marrow from homozygous mice
• 4.3-fold in aged mice due to enhanced myelopoiesis
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• in wild-type mice transplanted with bone marrow from homozygous mice
• in aged mice
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• in the bone marrow and spleen
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• mice exhibit an increase in Gr-1+/Mac-1+ cells compared with wild-type mice
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• mild in wild-type mice transplanted with bone marrow from homozygous mice
• 1.75-fold in aged mice
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• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells
• Background Sensitivity: mice on a congenic 129 background exhibit a greater reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a C57BL/6 congenic or mixed 129 and C57BL/6 background
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homeostasis/metabolism
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• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice
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cellular
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• mice exhibit reduced apoptosis in Ter-119+ cells, thymocytes, neutrophils, and mast cells compared with wild-type mice
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• spontaneous or dexamethasome-induced
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immune system
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• spontaneous or dexamethasome-induced
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• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice
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• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice
|
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• Gr-1+ cells exhibit a reduced rate of spontaneous and G-CSF deprivation-induced apoptosis compared with wild-type cells
|
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• aged mice exhibit enhanced myelopoiesis develop neutrophilia unlike wild-type mice
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• mice exhibit a 1.96-fold increase in white blood cell compared with wild-type mice
• the increase in white blood cell is severe in wild-type mice transplanted with bone marrow from homozygous mice
• at 18 months, mice exhibit increased white blood cells compared with wild-type mice
• however, the number of basophils is normal
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• in wild-type mice transplanted with bone marrow from homozygous mice
• 4.3-fold in aged mice due to enhanced myelopoiesis
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• in wild-type mice transplanted with bone marrow from homozygous mice
• in aged mice
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• in the bone marrow and spleen
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• mice exhibit an increase in Gr-1+/Mac-1+ cells compared with wild-type mice
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• mild in wild-type mice transplanted with bone marrow from homozygous mice
• 1.75-fold in aged mice
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• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells
• Background Sensitivity: mice on a congenic 129 background exhibit a greater reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a C57BL/6 congenic or mixed 129 and C57BL/6 background
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endocrine/exocrine glands
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• spontaneous or dexamethasome-induced
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• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice
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growth/size/body
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• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice
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