Phenotypes Associated with This Genotype

Genotype
MGI:5052138

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-PIK3CA*H1047R,-EGFP)Balj}/Gt(ROSA)26Sor⁺; Tg(Wap-cre)1Gsc/0
• Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:173655 )

• parous mice develop mammary tumors 37 days after delivery of pups (at 140 days) unlike Tg(Wap-cre)1Gsc mice

• mammary tumors are heterogeneous (adenosquamous carcinoma, adenomyoepitheliomas, adenocarcinomas with squamouse metaplasia, adenocarcinomas, and adenocarcinomatosis)

increased mammary adenocarcinoma incidence ( J:173655 )

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:173655 )

♀ • delayed due to reduced cell death

increased mammary gland tumor incidence ( J:173655 )

• parous mice develop mammary tumors 37 days after delivery of pups (at 140 days) unlike Tg(Wap-cre)1Gsc mice

• mammary tumors are heterogeneous (adenosquamous carcinoma, adenomyoepitheliomas, adenocarcinomas with squamouse metaplasia, adenocarcinomas, and adenocarcinomatosis)

increased mammary adenocarcinoma incidence ( J:173655 )

integument

abnormal involution of the mammary gland ( J:173655 )

♀ • delayed due to reduced cell death

increased mammary gland tumor incidence ( J:173655 )

• parous mice develop mammary tumors 37 days after delivery of pups (at 140 days) unlike Tg(Wap-cre)1Gsc mice

• mammary tumors are heterogeneous (adenosquamous carcinoma, adenomyoepitheliomas, adenocarcinomas with squamouse metaplasia, adenocarcinomas, and adenocarcinomatosis)

increased mammary adenocarcinoma incidence ( J:173655 )