About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5049864
Allelic
Composition		 Leprtm1.1Rll/Leprtm1.1Rll
Genetic
Background		 129P3/J-Leprtm1.1Rll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Rll mutation (0 available); any Lepr mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increased susceptibility to E. histolytica infection in Leprtm1.1Rll/Leprtm1.1Rll mice

immune system
increased susceptibility to parasitic infection ( J:172012 )
• E. histolytica-infected mice exhibit increased infection, more severe epithelial ulceration, and greater intestinal epithelial cell apoptosis compared to in similarly treated wild-type mice

digestive/alimentary system
increased enterocyte apoptosis ( J:172012 )
• in E. histolytica-infected mice

cellular
increased enterocyte apoptosis ( J:172012 )
• in E. histolytica-infected mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory