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Phenotypes Associated with This Genotype
Genotype
MGI:5014088
Allelic
Composition		 Pmltm1(PML/RARA)Ley/Pml+
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (16 available); any Lyz2 mutation (40 available)
Pmltm1(PML/RARA)Ley mutation (1 available); any Pml mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leukemia incidence ( J:172024 )
• one mouse exhibit rare leukemia with acute promyelocytic leukemia features

hematopoietic system
hematopoietic system phenotype ( J:172024 )
N
• hematopoietic stem cells exhibit normal ex vivo self-renewal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory