Phenotypes Associated with This Genotype

Genotype
MGI:5013958

• Allelic Composition: Pinx1^tm1.1Kplu/Pinx1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Varied histopathology of Pinx1^tm1.1Kplu/Pinx1⁺ tumors

mortality/aging

prenatal lethality, incomplete penetrance ( J:171997 )

• some mice die in utero

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:171997 )

• 10% of tumors in the stomach, small intestine, colon, and rectum

neoplasm

increased tumor incidence ( J:171997 )

• 49 of 52 mice between 9 and 18 months of age develop tumors (lung cancer, liver cancer, mammary cancer, and gastrointestinal tract tumors)

• tumors exhibit nuclear atypia, desmoplasia, stromal invasion, and/or distant metastasis

• mice develop lung metastasis from lung cancer or mammary cancer

• tumors exhibit telomere elongation, anaphase bridges, and/or lagging chromosomes

increased gastrointestinal tumor incidence ( J:171997 )

• 10% of tumors in the stomach, small intestine, colon, and rectum

increased mammary gland tumor incidence ( J:171997 )

• 13% of tumors

increased Harderian gland adenoma incidence ( J:171997 )

• 3% of tumors are eye Harderian gland adenoma

increased liver tumor incidence ( J:171997 )

• 18% of tumors

increased hibernoma incidence ( J:171997 )

• 2% of tumors

increased lymphoma incidence ( J:171997 )

• 7% of tumors

increased histiocytic sarcoma incidence ( J:171997 )

• 3% of tumors

increased carcinoma incidence ( J:171997 )

• 2% of tumors are leiomyocarcinoma

increased sarcoma incidence ( J:171997 )

• 2% of tumors are undifferentiated sarcoma

increased hemangiosarcoma incidence ( J:171997 )

• 2% of tumors

increased lung tumor incidence ( J:171997 )

• 37% of tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:171997 )

• 13% of tumors

increased Harderian gland adenoma incidence ( J:171997 )

• 3% of tumors are eye Harderian gland adenoma

liver/biliary system

increased liver tumor incidence ( J:171997 )

• 18% of tumors

cellular

increased telomere length ( J:171997 )

• elongated in tumor cells

chromosomal instability ( J:171997 )

• tumors exhibit anaphase bridges and/or lagging chromosomes, indicating chromosome instability

respiratory system

increased lung tumor incidence ( J:171997 )

• 37% of tumors

integument

increased mammary gland tumor incidence ( J:171997 )

• 13% of tumors

skin hyperplasia ( J:171997 )

• 3% of tumors