Phenotypes Associated with This Genotype

Genotype
MGI:5013717

• Allelic Composition: Birc2^tm1Rbr/Birc2^tm1Rbr; Birc3^tm1.1Rbr/Birc3^tm1.1Rbr; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell apoptosis ( J:172843 )

enlarged spleen ( J:172843 )

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice

increased B cell number ( J:172843 )

• in the lymph nodes, follicular, and marginal zone

increased follicular B cell number ( J:172843 )

increased marginal zone B cell number ( J:172843 )

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

enlarged lymph nodes ( J:172843 )

hematopoietic system

decreased B cell apoptosis ( J:172843 )

enlarged spleen ( J:172843 )

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice

increased B cell number ( J:172843 )

• in the lymph nodes, follicular, and marginal zone

increased follicular B cell number ( J:172843 )

increased marginal zone B cell number ( J:172843 )

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

cellular

decreased B cell apoptosis ( J:172843 )

growth/size/body

enlarged spleen ( J:172843 )