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Phenotypes Associated with This Genotype
Genotype
MGI:5013604
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Cop1tm2.1Vmd/Cop1tm2.1Vmd
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 B6N.CgCop1tm2.1Vmd Ptentm1Hwu Tg(Pbsn-cre)4Prb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cop1tm2.1Vmd mutation (0 available); any Cop1 mutation (42 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (87 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate gland adenocarcinoma incidence ( J:172653 )
• invasive in 11 of 13 mice at 30 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• high grade in 2 of 13 mice at 30 weeks of age

reproductive system
increased prostate gland adenocarcinoma incidence ( J:172653 )
• invasive in 11 of 13 mice at 30 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• high grade in 2 of 13 mice at 30 weeks of age

endocrine/exocrine glands
increased prostate gland adenocarcinoma incidence ( J:172653 )
• invasive in 11 of 13 mice at 30 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• high grade in 2 of 13 mice at 30 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory