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Phenotypes Associated with This Genotype
Genotype
MGI:5013467
Allelic
Composition		 Cd40tm1Kik/Cd40tm1Kik
Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (11 available); any Cd40 mutation (42 available)
Tnfsf11tm1Pngr mutation (0 available); any Tnfsf11 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymus epithelium morphology ( J:173115 )
• mice exhibit reduced MHC IIhigh and MHC IIlow medullary thymic epithelial cells (mTEC) compared with wild-type mice
• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

hematopoietic system
abnormal thymus epithelium morphology ( J:173115 )
• mice exhibit reduced MHC IIhigh and MHC IIlow medullary thymic epithelial cells (mTEC) compared with wild-type mice
• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

endocrine/exocrine glands
abnormal thymus epithelium morphology ( J:173115 )
• mice exhibit reduced MHC IIhigh and MHC IIlow medullary thymic epithelial cells (mTEC) compared with wild-type mice
• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory