Phenotypes Associated with This Genotype

Genotype
MGI:5013463

• Allelic Composition: Cd40^tm1Kik/Cd40^tm1Kik; Ltbr^tm1Mmat/Ltbr^tm1Mmat
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:173115 )

N • unlike Ltbr^tm1Mmat homozygotes, mice do not exhibit lymphoid cell aggregates

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer MHC II^low medullary thymic epithelial cells compared to in wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer MHC II^low medullary thymic epithelial cells compared to in wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer MHC II^low medullary thymic epithelial cells compared to in wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice