Phenotypes for Dkk1 Pax8 MGI:5013426 MGI Mouse

increased kidney cell proliferation ( J:173125 )

• mice exhibit increased proliferation of epithelial tubules of the developing kidney papilla compared with wild-type mice

decreased urine creatinine level ( J:173125 )

decreased urine glucose level ( J:173125 )

increased urine calcium level ( J:173125 )

increased urine chloride ion level ( J:173125 )

• mice exhibit increased chloride in the urine compared with wild-type mice

decreased urine potassium level ( J:173125 )

decreased urine sodium level ( J:173125 )

decreased urine protein level ( J:173125 )

decreased urine phosphate level ( J:173125 )

abnormal kidney collecting duct epithelium morphology ( J:173125 )

• mice exhibit hypertrophic collecting duct epithelial cells at the tip of the extended renal papilla compared with wild-type mice

abnormal kidney medulla morphology ( J:173125 )

elongated kidney papilla ( J:173125 )

• mice exhibit overgrowth of renal papilla in proportion to the rest of the kidney unlike in wild-type mice

• the papilla in the medulla extends over the lateral edge of the kidney capsule and reached the epithelial lining of the lumen of the ureter outside the kidney unlike in wild-type mice

• 7 of 10 mice exhibit over extended papilla unlike in wild-type mice

hydronephrosis ( J:173125 )

• in 2 of 10 mice

oliguria ( J:173125 )