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Phenotypes Associated with This Genotype
Genotype
MGI:5009548
Allelic
Composition		 Stat3tm1Vpo/Stat3tm1Vpo
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Stat3tm1Vpo mutation (0 available); any Stat3 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:172422 )
• mutants exhibit an increase in hepatocellular carcinoma development (increase in tumor number and size) after diethylnitrosamine (DEN) injection compared to controls

neoplasm
increased incidence of tumors by chemical induction ( J:172422 )
• mutants exhibit an increase in hepatocellular carcinoma development (increase in tumor number and size) after diethylnitrosamine (DEN) injection compared to controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory