Phenotypes Associated with This Genotype

Genotype
MGI:5009547

• Allelic Composition: Ptpn11^tm1Gsf/Ptpn11^tm1Gsf; Stat3^tm1Vpo/Stat3^tm1Vpo; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating alanine transaminase level ( J:172422 )

• increase in serum ALT levels, however ALT levels are lower than in single conditional Ptpn11 mice

increased incidence of tumors by chemical induction ( J:172422 )

• mutants exhibit an increase in hepatocellular carcinoma development after diethylnitrosamine (DEN) injection compared to controls and single conditional Ptpn11 mutants, however tumor frequency and size are similar to that seen in single conditional Stat3 mutants

immune system

liver inflammation ( J:172422 )

• infiltrate of inflammatory cells is seen in the portal triads of livers

• double mutants show less inflammation than seen in single conditional Ptpn11 mice, with reduced size of eosinophilic vacuoles of degeneration in the liver

liver/biliary system

liver inflammation ( J:172422 )

• infiltrate of inflammatory cells is seen in the portal triads of livers

• double mutants show less inflammation than seen in single conditional Ptpn11 mice, with reduced size of eosinophilic vacuoles of degeneration in the liver

neoplasm

increased incidence of tumors by chemical induction ( J:172422 )

• mutants exhibit an increase in hepatocellular carcinoma development after diethylnitrosamine (DEN) injection compared to controls and single conditional Ptpn11 mutants, however tumor frequency and size are similar to that seen in single conditional Stat3 mutants