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Phenotypes Associated with This Genotype
Genotype
MGI:5009307
Allelic
Composition		 Atg3tm1.1Ywh/Atg3tm1.1Ywh
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3tm1.1Ywh mutation (0 available); any Atg3 mutation (19 available)
Gt(ROSA)26Sortm1(cre/ERT)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (1062 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell apoptosis ( J:172749 )
• following tamoxifen stimulation
• however, apoptosis is rescued by IL7 treatment
abnormal T cell morphology ( J:172749 )
• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

hematopoietic system
increased T cell apoptosis ( J:172749 )
• following tamoxifen stimulation
• however, apoptosis is rescued by IL7 treatment
abnormal T cell morphology ( J:172749 )
• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

cellular
increased T cell apoptosis ( J:172749 )
• following tamoxifen stimulation
• however, apoptosis is rescued by IL7 treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory