Phenotypes Associated with This Genotype

Genotype
MGI:5009306

• Allelic Composition: Atg3^tm1.1Ywh/Atg3^tm1.1Ywh; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired autophagy ( J:172749 )

• T cells stimulated with anti-CD3 antibodies exhibit impaired autophagy compared with wild-type cells

immune system

increased T cell apoptosis ( J:172749 )

• in the spleen

decreased T cell proliferation ( J:172749 )

• of T cells stimulated with anti-CD3 antibodies

thymus hypoplasia ( J:172749 )

abnormal T cell morphology ( J:172749 )

• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:172749 )

• in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:172749 )

• in the spleen

spleen hypoplasia ( J:172749 )

cellular

impaired autophagy ( J:172749 )

• T cells stimulated with anti-CD3 antibodies exhibit impaired autophagy compared with wild-type cells

increased T cell apoptosis ( J:172749 )

• in the spleen

decreased T cell proliferation ( J:172749 )

• of T cells stimulated with anti-CD3 antibodies

oxidative stress ( J:172749 )

• T cells exhibit overproduction of reactive oxygen species compared with wild-type cells

hematopoietic system

increased T cell apoptosis ( J:172749 )

• in the spleen

decreased T cell proliferation ( J:172749 )

• of T cells stimulated with anti-CD3 antibodies

thymus hypoplasia ( J:172749 )

abnormal T cell morphology ( J:172749 )

• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:172749 )

• in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:172749 )

• in the spleen

spleen hypoplasia ( J:172749 )

endocrine/exocrine glands

thymus hypoplasia ( J:172749 )