Phenotypes Associated with This Genotype

Genotype
MGI:5008743

• Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv; Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

emphysema ( J:100854 )

• following treatment with doxycycline but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

abnormal lung volume ( J:100854 )

• doxycycline-treated mice exhibit increased lung volume compared to in wild-type mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

increased lung compliance ( J:100854 )

• following treatment with doxycycline but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

immune system

increased neutrophil cell number ( J:100854 )

• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

increased lymphocyte cell number ( J:100854 )

• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

increased macrophage cell number ( J:100854 )

• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

cellular

increased apoptosis ( J:100854 )

• in lung cells following treatment with doxycycline but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

hematopoietic system

increased neutrophil cell number ( J:100854 )

• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

increased lymphocyte cell number ( J:100854 )

• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice

increased macrophage cell number ( J:100854 )

• in the bronchoalveolar lavage of doxycycline-treated mice but not as much as in Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli mice