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Phenotypes Associated with This Genotype
Genotype
MGI:5008586
Allelic
Composition		 Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (1095 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (87 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
enlarged prostate gland anterior lobe ( J:170965 )
• in doxycycline-treated mice
increased prostate gland weight ( J:170965 )
• in doxycycline-treated mice
prostate gland hyperplasia ( J:170965 )
• in doxycycline-treated mice
increased prostate gland tumor incidence ( J:170965 )
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdk1tm1Dral homozygotes
abnormal prostate gland physiology ( J:170965 )
• doxycycline-treated mice exhibit increased proliferation in the prostate gland compared to in Pdk1tm1Dral homozygotes

neoplasm
increased prostate gland tumor incidence ( J:170965 )
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdk1tm1Dral homozygotes

endocrine/exocrine glands
enlarged prostate gland anterior lobe ( J:170965 )
• in doxycycline-treated mice
increased prostate gland weight ( J:170965 )
• in doxycycline-treated mice
prostate gland hyperplasia ( J:170965 )
• in doxycycline-treated mice
increased prostate gland tumor incidence ( J:170965 )
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdk1tm1Dral homozygotes
abnormal prostate gland physiology ( J:170965 )
• doxycycline-treated mice exhibit increased proliferation in the prostate gland compared to in Pdk1tm1Dral homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory