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Phenotypes Associated with This Genotype
Genotype
MGI:5008417
Allelic
Composition
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/0
Genetic
Background
B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(EGFP)Klt mutation (3 available); any Mapt mutation (402 available)
Tg(MAPT)8cPdav mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• 6 month old mutants exhibit slower visuospatial learning than control mice
• in the visuospatial re-learning test performed at 7, 8, 9, and 15 months of age, mutants exhibit a decrease in the speed of re-learning the task compared to controls
• however, mutants perform better than Tg(APPswe,PSEN1dE9)85Dbo mice on the visuospatial re-learning test at 9 and 18 months of age

taste/olfaction
N
• mutants do not exhibit Alzheimer's disease-related impairment in olfactory performance in tests based on an operant conditioning procedure and in tests based on a habituation/dishabituation procedure

nervous system

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:172426


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory