Phenotypes Associated with This Genotype

Genotype
MGI:5008263

• Allelic Composition: Tg(TSPY1-Figla)#Dean/?
• Genetic Background: FVB/N-Tg(TSPY1-Figla)#Dean

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

seminiferous tubule degeneration ( J:162655 )

♂ • tubules become increasingly vacuolar

♂ • by 7 months of age vacuolation is widespread and half of the tubules exhibit signs of degeneration

small testis ( J:162655 )

♂ • by 7 weeks of age testes are 27% smaller than controls

reproductive system

abnormal male germ cell morphology ( J:162655 )

♂ • germ cells exhibit loss of chromatoid body integrity

kinked sperm flagellum ( J:162655 )

♂ • 50% of sperm have severe tail angulation

abnormal spermatocyte morphology ( J:162655 )

♂ • by 7-8 weeks seminiferous tubules contain abnormally large spermatocytes

decreased male germ cell number ( J:162655 )

♂ • by 3 weeks of age seminiferous tubules contain fewer germ cells than controls

♂ • apoptotic germ cells are detected beginning at 4 months of age and become abundant by 5 months of age

oligozoospermia ( J:162655 )

♂ • 20% fewer sperm are recovered from 5 month old males than controls

arrest of male meiosis ( J:162655 )

♂ • by 5 months of age, multiple germ cells with tubules do not complete meiosis

♂ • meiotic progression is delayed or arrested in prophase I

abnormal sperm motility ( J:162655 )

♂ • sperm exhibits decreased motility, progressive motion and hyperactivity

seminiferous tubule degeneration ( J:162655 )

♂ • tubules become increasingly vacuolar

♂ • by 7 months of age vacuolation is widespread and half of the tubules exhibit signs of degeneration

small testis ( J:162655 )

♂ • by 7 weeks of age testes are 27% smaller than controls

male infertility ( J:162655 )

♂ • all males become infertile by 5 months of age although some become infertile as early as 3 months

impaired fertilization ( J:162655 )

• in-vitro fertilization (IVF) success rates decrease with the use of sperm from 2 month old males

• sperm from 5 month old males binds to ovulated eggs at much lower numbers than controls

cellular

abnormal male germ cell morphology ( J:162655 )

♂ • germ cells exhibit loss of chromatoid body integrity

kinked sperm flagellum ( J:162655 )

♂ • 50% of sperm have severe tail angulation

abnormal spermatocyte morphology ( J:162655 )

♂ • by 7-8 weeks seminiferous tubules contain abnormally large spermatocytes

decreased male germ cell number ( J:162655 )

♂ • by 3 weeks of age seminiferous tubules contain fewer germ cells than controls

♂ • apoptotic germ cells are detected beginning at 4 months of age and become abundant by 5 months of age

oligozoospermia ( J:162655 )

♂ • 20% fewer sperm are recovered from 5 month old males than controls

arrest of male meiosis ( J:162655 )

♂ • by 5 months of age, multiple germ cells with tubules do not complete meiosis

♂ • meiotic progression is delayed or arrested in prophase I

abnormal sperm motility ( J:162655 )

♂ • sperm exhibits decreased motility, progressive motion and hyperactivity