Phenotypes Associated with This Genotype

Genotype
MGI:5008147

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Rictor^tm1.1Mgn/Rictor^tm1.1Mgn; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:170129 )

• average beta cell size is increased by 31% compared to controls and by 15% compared to single conditional Pten mutants

• however, mutants show normal beta cell proliferation

decreased pancreatic beta cell mass ( J:170129 )

• beta cell mass is about 40% lower than that of single conditional Pten mutants

growth/size/body

postnatal growth retardation ( J:170129 )

homeostasis/metabolism

abnormal glucose homeostasis ( J:170129 )

• total glucose excursion is lower compared to single conditional Rictor mutants

hypoglycemia ( J:170129 )

• fed blood glucose concentration remains similar to the controls, however mutants show a lower blood glucose concentration at 30 and 60 min after an intraperitoneal glucose bolus compared to single conditional Rictor mutants

decreased circulating insulin level ( J:170129 )

• mutants exhibit lower plasma insulin levels 15 min after glucose challenge and lower total insulin output compared with controls

• however, insulin secretion by glucose stimulated islets is similar to controls and pancreatic insulin content is unchanged