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Phenotypes Associated with This Genotype
Genotype
MGI:5007684
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Tg(IghelMD4)4Ccg/0
Tg(ML5sHEL)5Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Tg(IghelMD4)4Ccg mutation (16 available)
Tg(ML5sHEL)5Ccg mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:155314 )
• low splenic and lymph node B cell numbers

immune system
immune system phenotype ( J:155314 )
N
• tolerance mechanisms to prevent autoantibody production are intact and B cells are able to selectively downregulate IgM
decreased B cell number ( J:155314 )
• low splenic and lymph node B cell numbers

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory