Phenotypes for Fas Fasl MGI:5006703 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fas^lpr/Fas^lpr Fasl^tm2.1Bksa/Fasl^tm2.1Bksa
Genetic Background	involves: 129 * C57BL/6 * MRL/Mp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^lpr mutation (39 available); any Fas mutation (83 available)
Fasl^tm2.1Bksa mutation (0 available); any Fasl mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:171440 )

N	• TNFalpha-treated mice do not exhibit a decrease in retinal nerve fibers like in similarly treated wild-type mice

abnormal retina ganglion cell morphology ( J:171440 )

• after 1 week, TNFalpha-treated mice fail to exhibit a decrease in retinal ganglion cells unlike in similarly treated wild-type mice

nervous system

abnormal retina ganglion cell morphology ( J:171440 )

• after 1 week, TNFalpha-treated mice fail to exhibit a decrease in retinal ganglion cells unlike in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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