Phenotypes Associated with This Genotype

Genotype
MGI:5004969

• Allelic Composition: Osr1^tm2.1Jian/Osr1^tm2.1Jian
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dilated epicardium, hemorrhaging, and edema in Osr1^tm2.1Jian/Osr1^tm2.1Jian embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:172133 )

• mice die around E12.0

embryo

embryonic growth arrest ( J:172133 )

abnormal forelimb bud morphology ( J:172133 )

• at E12.0, forelimb buds are abnormal compared with wild-type mice

cardiovascular system

abnormal epicardium morphology ( J:172133 )

• dilated epicardium

hemorrhage ( J:172133 )

• in the trunk

limbs/digits/tail

abnormal forelimb bud morphology ( J:172133 )

• at E12.0, forelimb buds are abnormal compared with wild-type mice

homeostasis/metabolism

edema ( J:172133 )

• generalized in mice that survive to mid-gestation