Phenotypes Associated with This Genotype

Genotype
MGI:5003280

• Allelic Composition: Cul4a^tm1.2Pra/Cul4a^tm1.2Pra
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

multinucleated giant male germ cells ( J:171470 )

♂ • multinucleated giant cells are detected unlike in Cul4a^tm1.1Pra homozygotes

increased male germ cell apoptosis ( J:171470 )

♂ • 9-fold increased compared with Cul4a^tm1.1Pra homozygotes

asthenozoospermia ( J:171470 )

♂ • very few sperm are motile unlike in Cul4a^tm1.1Pra homozygotes

small testis ( J:171470 )

♂

decreased testis weight ( J:171470 )

♂ • 2-fold

abnormal spermatogenesis ( J:171470 )

♂ • daily sperm production from spermatozoa is reduced compared to in Cul4a^tm1.1Pra homozygotes

♂ • seminiferous tubules exhibit premature sloughing of germ cells compared to in Cul4a^tm1.1Pra homozygotes

abnormal sperm flagellum morphology ( J:171470 )

♂ • sperm tails exhibit cytoplasmic droplets unlike cells from Cul4a^tm1.1Pra homozygotes

azoospermia ( J:171470 )

♂ • epididymal tubules lack sperm

oligozoospermia ( J:171470 )

♂ • mice exhibit a deficiency in postmeitotic cells (round, elongated spermatids and sperm cells) compared with Cul4a^tm1.1Pra homozygotes

♂ • the number of spermatozoa is decreased compared to in Cul4a^tm1.1Pra homozygotes

abnormal sperm head morphology ( J:171470 )

♂ • sperm cells exhibit oval small heads, are headless, or are decapitated compared to in Cul4a^tm1.1Pra homozygotes

abnormal spermatid morphology ( J:171470 )

♂

abnormal spermatocyte morphology ( J:171470 )

♂

abnormal male meiosis ( J:171470 )

♂ • the number of postmeitotic cells is decreased compared to in Cul4a^tm1.1Pra homozygotes

♂ • meiosis is delayed compared to in cells from Cul4a^tm1.1Pra homozygotes

♂ • however, mice exhibit normal synapsis of homologous chromosomes and formation of XY-body

small epididymis ( J:171470 )

♂ • 2-fold

reduced female fertility ( J:171470 )

♀ • female mice produce smaller litters than compared with Cul4a^tm1.1Pra homozygotes

decreased litter size ( J:171470 )

• female mice produce smaller litters than wild-type mice

• male mice are unable to produce any offspring unlike Cul4a^tm1.1Pra homozygotes

male infertility ( J:171470 )

♂

cellular

abnormal sperm flagellum morphology ( J:171470 )

♂ • sperm tails exhibit cytoplasmic droplets unlike cells from Cul4a^tm1.1Pra homozygotes

azoospermia ( J:171470 )

♂ • epididymal tubules lack sperm

oligozoospermia ( J:171470 )

♂ • mice exhibit a deficiency in postmeitotic cells (round, elongated spermatids and sperm cells) compared with Cul4a^tm1.1Pra homozygotes

♂ • the number of spermatozoa is decreased compared to in Cul4a^tm1.1Pra homozygotes

abnormal sperm head morphology ( J:171470 )

♂ • sperm cells exhibit oval small heads, are headless, or are decapitated compared to in Cul4a^tm1.1Pra homozygotes

abnormal spermatid morphology ( J:171470 )

♂

abnormal spermatocyte morphology ( J:171470 )

♂

multinucleated giant male germ cells ( J:171470 )

♂ • multinucleated giant cells are detected unlike in Cul4a^tm1.1Pra homozygotes

increased male germ cell apoptosis ( J:171470 )

♂ • 9-fold increased compared with Cul4a^tm1.1Pra homozygotes

asthenozoospermia ( J:171470 )

♂ • very few sperm are motile unlike in Cul4a^tm1.1Pra homozygotes

abnormal double-strand DNA break repair ( J:171470 )

♂ • pachytene spermatocytes exhibit impaired double-strand DNA repair compared with cell from Cul4a^tm1.1Pra homozygotes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:171470 )

♂ • pachytene spermatocytes exhibit impaired double-strand DNA repair compared with cell from Cul4a^tm1.1Pra homozygotes

endocrine/exocrine glands

small testis ( J:171470 )

♂

decreased testis weight ( J:171470 )

♂ • 2-fold