Phenotypes Associated with This Genotype

Genotype
MGI:5003062

• Allelic Composition: Anp32b^tm1Mak/Anp32b^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Kyphosis in Anp32b^tm1Mak/Anp32b^tm1Mak mice

mortality/aging

premature death ( J:172042 )

• mice that survive to adulthood exhibit decreased life span

perinatal lethality, incomplete penetrance ( J:172042 )

• most mice die between E17.5 and the first 12 hours after birth

• Background Sensitivity: fewer mice die on a mixed background compared with mice on a congenic C57BL/6 background

• however, mice that are detected at 12 hours exhibit normal survival to adulthood

premature aging ( J:172042 )

• many mice exhibit early onset of aging symptoms (kyphosis and hepatocyte polyploidy) compared with wild-type mice

• however, mice do not exhibit alopecia

craniofacial

abnormal craniofacial morphology ( J:172042 )

• in some mice

cleft palate ( J:172042 )

• some mice exhibit palate closure defect compared with wild-type mice

nervous system

enlarged brain ventricles ( J:172042 )

• some mice exhibit overlarge brain ventricles compared with wild-type mice

respiratory system

primary atelectasis ( J:172042 )

• some mice never initiate breathing

cardiovascular system

hematoma ( J:172042 )

• in the liver, aortic arch, or umbilical artery of 3 of 8 mice at E17.5

• in the liver, aortic arch, or umbilical artery of 1 of 3 mouse at P1

growth/size/body

cleft palate ( J:172042 )

• some mice exhibit palate closure defect compared with wild-type mice

decreased body size ( J:172042 )

• in surviving mice

decreased body weight ( J:172042 )

• in surviving mice

hearing/vestibular/ear

abnormal inner ear morphology ( J:172042 )

• some mice exhibit expanded inner ear cavities compared with wild-type mice

renal/urinary system

hydroureter ( J:172042 )

• in 2 of 7 mice

cellular

cellular phenotype ( J:172042 )

N • apoptosis and proliferation in thymocytes, primary and transformed mouse embryonic fibroblasts, and splenocytes are normal

polyploidy ( J:172042 )

• premature onset in the hepatocytes of many mice

digestive/alimentary system

cleft palate ( J:172042 )

• some mice exhibit palate closure defect compared with wild-type mice

megacolon ( J:172042 )

• in 2 of 7 mice

skeleton

kyphosis ( J:172042 )

• premature onset in many mice