Phenotypes Associated with This Genotype

Genotype
MGI:5002664

• Allelic Composition: Pdcd10^tm1Wami/Pdcd10^tm1Wami; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129 * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171969 )

• normal Mendelian ratios cannot be detected after E9.5

• no mice are present after E10.5

cardiovascular system

abnormal brain vasculature morphology ( J:171969 )

• mice exhibit abnormal angiogenesis and remodeling in the telencephalic plexus compared with wild-type mice

abnormal intersomitic vessel morphology ( J:171969 )

• intersomitic vessels are poorly organized and less branched compared to in wild-type mice

abnormal angiogenesis ( J:171969 )

• mice exhibit abnormal angiogenesis and remodeling in the yolk sac, telencephalic plexus, and intersomitic vasculature compared with wild-type mice

• angiogenesis is delayed compared to in wild-type mice

abnormal dorsal aorta morphology ( J:171969 )

• disorganized and discontinued

dilated dorsal aorta ( J:171969 )

abnormal developmental vascular remodeling ( J:171969 )

• mice exhibit abnormal angiogenesis and remodeling in the yolk sac, telencephalic plexus, and intersomitic vasculature compared with wild-type mice

abnormal vascular branching morphogenesis ( J:171969 )

abnormal cardinal vein morphology ( J:171969 )

• dilated, disorganized, and discontinued

abnormal vitelline vasculature morphology ( J:171969 )

• mice exhibit abnormal angiogenesis and remodeling in the yolk sac compared with wild-type mice

• the yolk sac contains fewer blood vessels compared to in wild-type mice

abnormal myocardium layer morphology ( J:171969 )

• the endocardium is dissociated from the myocardium unlike in wild-type mice

myocardial trabeculae hypoplasia ( J:171969 )

thin myocardium ( J:171969 )

abnormal endocardium morphology ( J:171969 )

• the endocardium is dissociated from the myocardium unlike in wild-type mice

enlarged pericardium ( J:171969 )

hematopoietic system

anemia ( J:171969 )

• at E8.5

impaired hematopoiesis ( J:171969 )

nervous system

nervous system phenotype ( J:171969 )

N • neural tube closure is normal

abnormal brain vasculature morphology ( J:171969 )

• mice exhibit abnormal angiogenesis and remodeling in the telencephalic plexus compared with wild-type mice

embryo

abnormal vitelline vasculature morphology ( J:171969 )

• mice exhibit abnormal angiogenesis and remodeling in the yolk sac compared with wild-type mice

• the yolk sac contains fewer blood vessels compared to in wild-type mice

abnormal vitelline vascular remodeling ( J:171969 )

muscle

abnormal myocardium layer morphology ( J:171969 )

• the endocardium is dissociated from the myocardium unlike in wild-type mice

myocardial trabeculae hypoplasia ( J:171969 )

thin myocardium ( J:171969 )

integument

pallor ( J:171969 )

• at E8.5

growth/size/body

microcephaly ( J:171969 )