Phenotypes Associated with This Genotype

Genotype
MGI:5000476

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; Tg(MMTV-cre)1Mam/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:170898 )

• survival time is reduced compared to mutant mice carrying Tg(MMTV-cre)4Mam

neoplasm

increased tumor incidence ( J:170898 )

• develop a more diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)4Mam

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 42% of mice have palpable mammary tumors at the time of death

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 42% of mice have palpable mammary tumors at the time of death

integument

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 42% of mice have palpable mammary tumors at the time of death