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Phenotypes Associated with This Genotype
Genotype
MGI:5000444
Allelic
Composition		 Cd19tm1Tft/Cd19tm1Tft
Lyntm1Sor/Lyntm1Sor
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1Tft mutation (0 available); any Cd19 mutation (61 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:71174 )
N
• IgA, IgM, and IgG levels are the same as in wild-type mice
decreased B cell proliferation ( J:71174 )
• in response to BCR ligation or LPS stimulation
enlarged spleen ( J:71174 )
• but not as much as in Lyntm1Sor homozygotes
decreased B cell number ( J:71174 )
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
decreased mature B cell number ( J:71174 )
• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice
abnormal humoral immune response ( J:71174 )
• after immunization, anti-DNP IgM antibody production is delayed compared with wild-type mice
• IgG1 response is delayed and modest compared to in wild-type mice
decreased susceptibility to systemic lupus erythematosus ( J:71174 )
• compared with Lyntm1Sor homozygotes
decreased anti-double stranded DNA antibody level ( J:71174 )
• compared with Lyntm1Sor homozygotes

hematopoietic system
decreased B cell proliferation ( J:71174 )
• in response to BCR ligation or LPS stimulation
enlarged spleen ( J:71174 )
• but not as much as in Lyntm1Sor homozygotes
decreased B cell number ( J:71174 )
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
decreased mature B cell number ( J:71174 )
• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice

cellular
decreased B cell proliferation ( J:71174 )
• in response to BCR ligation or LPS stimulation

growth/size/body
enlarged spleen ( J:71174 )
• but not as much as in Lyntm1Sor homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory