Phenotypes Associated with This Genotype

Genotype
MGI:5000443

• Allelic Composition: Lyn^tm1Sor/Lyn^tm1Sor
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:71174 )

• in response to BCR ligation

• however, B cell proliferation in response to LPS stimulation is normal

enlarged spleen ( J:71174 )

decreased B cell number ( J:71174 )

• bone marrow exhibit a modest decrease in IgM-B220^low pro/pre B cells or IgM+ B220^low immature B cells compared with wild-type mice

• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice

decreased mature B cell number ( J:71174 )

decreased B-1 B cell number ( J:71174 )

increased IgA level ( J:71174 )

increased IgG level ( J:71174 )

• in the serum and kidney deposits

increased IgG1 level ( J:71174 )

increased IgG2b level ( J:71174 )

increased IgM level ( J:71174 )

increased susceptibility to systemic lupus erythematosus ( J:71174 )

increased anti-double stranded DNA antibody level ( J:71174 )

glomerulonephritis ( J:71174 )

renal/urinary system

glomerulonephritis ( J:71174 )

hematopoietic system

increased B cell proliferation ( J:71174 )

• in response to BCR ligation

• however, B cell proliferation in response to LPS stimulation is normal

enlarged spleen ( J:71174 )

decreased B cell number ( J:71174 )

• bone marrow exhibit a modest decrease in IgM-B220^low pro/pre B cells or IgM+ B220^low immature B cells compared with wild-type mice

• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice

decreased mature B cell number ( J:71174 )

decreased B-1 B cell number ( J:71174 )

increased IgA level ( J:71174 )

increased IgG level ( J:71174 )

• in the serum and kidney deposits

increased IgG1 level ( J:71174 )

increased IgG2b level ( J:71174 )

increased IgM level ( J:71174 )

cellular

increased B cell proliferation ( J:71174 )

• in response to BCR ligation

• however, B cell proliferation in response to LPS stimulation is normal

growth/size/body

enlarged spleen ( J:71174 )