Phenotypes Associated with This Genotype

Genotype
MGI:4999807

• Allelic Composition: Nek7^tm1Mot/Nek7^tm1Mot
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:168166 )

perinatal lethality, incomplete penetrance ( J:168166 )

• only about 1% newborn are homozygous when heterozygous are crossed

postnatal lethality, incomplete penetrance ( J:168166 )

• most of homozygous newborns die within their first 2 weeks

embryonic lethality during organogenesis, incomplete penetrance ( J:168166 )

preweaning lethality, complete penetrance ( J:168166 )

• homozygous newborns rarely survive up to 1 month

• Background Sensitivity: survival of homozygous mice in a mixed 129/ICR background survive longer then C57BL/6 or BALB/c background, however author did not show any data

growth/size/body

decreased birth weight ( J:168166 )

• homozygous mutant neonates weighed slightly less than their littermates at birth

postnatal growth retardation ( J:168166 )

• after birth homozygous mouse shows a severe retardation in weight gain

• less than 50% of the weight of there wild type or heterozygous siblings at postnatal day 20

cellular

binucleate ( J:168166 )

• early passage of the MEF derived from E13.5 homozygous embryo exhibit increased binuclear phenotype

aneuploidy ( J:168166 )

• higher frequency of aneuploidy in homozygous embryo derived MEF

polyploidy ( J:168166 )

• 4N tetraploidy cell population are elevated in homozygous embryo derived MEF

abnormal mitosis ( J:168166 )

• homozygous embryo derived MEF show disturbed frequency of primary cilia from multiple basal bodies

• do not exhibit metaphase arrest

• centrosome duplication is not affected

chromosomal instability ( J:168166 )

• chromosomal counts of colcemid-arrested metaphase spreads of MEF derived from homozygous embryo shows increased chromosome content