Phenotypes Associated with This Genotype

Genotype
MGI:4950281

• Allelic Composition: Ccl2^tm1.1Pame/Ccl2^tm1.1Pame; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:171379 )

• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice

• mice exposed to L. monocytogenes exhibit reduced Ly6C^hi monocyte emigration from the bone marrow compared with similarly treated wild-type mice

increased susceptibility to bacterial infection ( J:171379 )

• mice exposed to L. monocytogenes exhibit reduced Ly6C^hi monocyte emigration from the bone marrow compared with similarly treated wild-type mice

cellular

abnormal leukocyte migration ( J:171379 )

• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice

• mice exposed to L. monocytogenes exhibit reduced Ly6C^hi monocyte emigration from the bone marrow compared with similarly treated wild-type mice

hematopoietic system

abnormal leukocyte migration ( J:171379 )

• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice

• mice exposed to L. monocytogenes exhibit reduced Ly6C^hi monocyte emigration from the bone marrow compared with similarly treated wild-type mice