Phenotypes Associated with This Genotype

Genotype
MGI:4949724

• Allelic Composition: Pikfyve^tm1.2Ashi/Pikfyve^tm1.2Ashi
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:171129 )

• all mice die during the preimplantation period prior to 32-64 cell stage

embryonic lethality before implantation, incomplete penetrance ( J:171129 )

• fewer than expected mice are present at E3.5

embryo

abnormal blastocyst morphology ( J:171129 )

• preimplantation embryos are morbid with increased cellular fragmentation and reduced cells numbers in the inner cell mass and trophectoderm compared with wild-type embryos

abnormal blastocoele morphology ( J:171129 )

• embryos either fail to cavitate or fail to maintain the blastocoel unlike wild-type mice

absent blastocoele ( J:171129 )

• in some embryos

abnormal inner cell mass morphology ( J:171129 )

• fewer cells are present in the inner cell mass than in wild-type embryos

• inner cell mass cells exhibit vacuolation unlike in wild-type embryos

abnormal trophectoderm morphology ( J:171129 )

• fewer cells are present in the trophectoderm than in wild-type embryos