Phenotypes Associated with This Genotype

Genotype
MGI:4947985

• Allelic Composition: Ntrk2^tm1Bxu/Ntrk2^tm1Bxu
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:170724 )

N • mice survive well

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:170724 )

• nigrostriatal dopaminergic neurons are more vulnerable to MPTP than wild-type cells

gliosis ( J:170724 )

• in the striatum without a reduction in the total number of neurons

abnormal innervation ( J:170724 )

• mice exhibit a loss of nigrostriatal dopaminergic projections compared with wild-type mice

abnormal dopaminergic neuron morphology ( J:170724 )

• mice exhibit a loss of nigrostriatal dopaminergic projections compared with wild-type mice

decreased dopaminergic neuron number ( J:170724 )

• reduced by 22% at 12 months, 29% at 18 months, and 26% at 24 months

neurodegeneration ( J:170724 )

• mice exhibit late-onset and selective nigrostriatal degeneration of dopaminergic neurons

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:170724 )

• nigrostriatal dopaminergic neurons are more vulnerable to MPTP than wild-type cells

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:170724 )

• nigrostriatal dopaminergic neurons are more vulnerable to MPTP than wild-type cells