Phenotypes Associated with This Genotype

Genotype
MGI:4947940

• Allelic Composition: Fas^lpr/Fas^lpr; Tcra^tm1Mjo/Tcra^tm1Mjo
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:38492 )

• relative to mutant mice wild-type for Tcra

immune system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins, other than IgE, compared to mutant mice wild-type for Tcra

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Tcra

integument

skin lesions ( J:38492 )

• development of skin lesions is delayed (develop by 7 to 8 months of age) compared to mutant mice wild-type by Tcra

renal/urinary system

abnormal kidney morphology ( J:38492 )

• substantial reduction in renal disease compared to mutant mice wild-type for Tcra

hematopoietic system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins, other than IgE, compared to mutant mice wild-type for Tcra