Phenotypes Associated with This Genotype

Genotype
MGI:4947400

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Crp^tm1Hjf/Crp^tm1Hjf
• Genetic Background: B6.Cg-Crp^tm1Hjf Apoe^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:170409 )

• in female mice fed a low-fat, semi-synthetic diet at 16 weeks of age

increased circulating HDL cholesterol level ( J:170409 )

• in female mice fed a low-fat, semi-synthetic diet at 16 weeks of age

decreased circulating triglyceride level ( J:170409 )

• in female mice fed a low-fat, semi-synthetic diet at 12 weeks of age

cardiovascular system

increased susceptibility to atherosclerosis ( J:170409 )

• at 12 weeks of age, female mice fed a low-fat, semi-synthetic diet exhibit an increase in susceptibility to atherosclerosis in the aortic root compared with Apoe^tm1Unc homozygotes

• at 16 weeks of age, male mice fed a low-fat, semi-synthetic diet exhibit an increase in susceptibility to atherosclerosis in the aortic root compared with Apoe^tm1Unc homozygotes