About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4947235
Allelic
Composition
Rhotm1.1Kpal/Rho+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1.1Kpal mutation (1 available); any Rho mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Retinal degeneration in Rhotm1.1Kpal/Rho+ and Rhotm1.1Kpal/Rhotm1.1Kpal mice

vision/eye
• the distance between retina pigmented epithelium and the outer limiting membrane is reduced compared to in wild-type mice
• half the number in wild-type mice
• due to necrosis
• mildly reduced at P70
• severely depressed at P170
• continuous decline until P276
• severely reduced at P41
• nearly undetectable by P170

nervous system
• half the number in wild-type mice
• due to necrosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:170648


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/03/2020
MGI 6.15
The Jackson Laboratory