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Phenotypes Associated with This Genotype
Genotype
MGI:4946938
Allelic
Composition		 Xrcc1tm1Pmc/Xrcc1tm1Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Xrcc1tm1Pmc mutation (1 available); any Xrcc1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA repair ( J:170077 )
• astrocytes exhibit unrepaired DNA damage in response to ionizing radiation, hydrogen peroxide, and ultraviolet irradiation compared with similarly treated wild-type cells

homeostasis/metabolism
abnormal DNA repair ( J:170077 )
• astrocytes exhibit unrepaired DNA damage in response to ionizing radiation, hydrogen peroxide, and ultraviolet irradiation compared with similarly treated wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory