Phenotypes Associated with This Genotype

Genotype
MGI:4946621

• Allelic Composition: Apc^Min/Apc⁺; Cd44^tm1Mak/Cd44^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased intestinal adenoma incidence ( J:135025 )

• an almost 50% reduction in intestinal adenoma number at 16 weeks

• strongly reduced number of aberrant crypts both at 8 weeks and at 16 weeks

• no change in mean adenoma diameter

digestive/alimentary system

increased small intestinal crypt cell apoptosis ( J:135025 )

• increased number of apoptotic cells in the intestinal crypt compartments shown by cleaved caspase-3 staining

• majority of these positive cells are localized below the transit-amplifying zone in the basal crypt compartment, between Paneth cells

• no change in proliferation

decreased intestinal adenoma incidence ( J:135025 )

• an almost 50% reduction in intestinal adenoma number at 16 weeks

• strongly reduced number of aberrant crypts both at 8 weeks and at 16 weeks

• no change in mean adenoma diameter

cellular

increased small intestinal crypt cell apoptosis ( J:135025 )

• increased number of apoptotic cells in the intestinal crypt compartments shown by cleaved caspase-3 staining

• majority of these positive cells are localized below the transit-amplifying zone in the basal crypt compartment, between Paneth cells

• no change in proliferation