Phenotypes Associated with This Genotype

Genotype
MGI:4946521

• Allelic Composition: Cd44^tm1Mak/Cd44^tm1Mak; Met^tm1Cbm/Met⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 70% of the animals die of breathing difficulties

neonatal lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 70% of the animals die of breathing difficulties

respiratory system

primary atelectasis ( J:128984 )

• multifocal atelectasis in the lung caused by a primary asphyxia

• in 76% of the mutant animals, the lungs sank, indicating that they are not inflated

respiratory distress ( J:128984 )

• shortly after birth, 70% of the animals die of breathing difficulties

nervous system

abnormal phrenic nerve morphology ( J:128984 )

• individual Schwann cell profiles ensheath more axons than in control mice

• less Schwann cell profiles than in controls ensheath only one axon

• increased number of Schwann cells associated with bundles of axons without intervening Schwann cell processes

• reduced number of segregated axons

• decreased percentage of segregated axons with a diameter size between 0.75 to 1.00 um

• slightly increased percentage of small (<0.75 um) and large (>1.00 um) caliber axons

abnormal miniature excitatory postsynaptic currents ( J:128984 )

• even more severe impairment of excitatory synaptic transmission in preBotC neurons

• decreased frequency of glutamatergic mEPSCs in preBotC neurons, compare with Cd44^tm1Mak homozygous mice

• moderately decreased amplitude

abnormal miniature inhibitory postsynaptic currents ( J:128984 )

• reduced spontaneous postsynaptic currents (sPSCs) in preBotC neurons

• amplitudes are not changed

decreased miniature inhibitory postsynaptic current frequency ( J:128984 )

• decreased frequency of glycinergic and GABAergic miniature mIPSCs in preBotC neurons