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Phenotypes Associated with This Genotype
Genotype
MGI:4946295
Allelic
Composition
Trp53tm1Brd/Trp53tm8Xu
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Brd mutation (7 available); any Trp53 mutation (150 available)
Trp53tm8Xu mutation (0 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 6 weeks of age
• mice exhibit aging-related phenotypes including acute spine curvature, bone marrow hypoplasia, lymphopenia, and anemia unlike wild-type mice

reproductive system
• progressive
• the number of spermatogonial stem cells is depleted compared to in wild-type mice

hematopoietic system
• progressive
• by 2 weeks of age
• in the fetal liver and bone marrow

growth/size/body
• by 2 weeks of age
• by 4 weeks of age

nervous system

skeleton

digestive/alimentary system

endocrine/exocrine glands
• progressive

immune system
• by 2 weeks of age

cellular


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory