mortality/aging
• by 6 weeks of age
|
• mice exhibit aging-related phenotypes including acute spine curvature, bone marrow hypoplasia, lymphopenia, and anemia unlike wild-type mice
|
reproductive system
small testis
(
J:170216
)
• progressive
|
• the number of spermatogonial stem cells is depleted compared to in wild-type mice
|
hematopoietic system
• by 2 weeks of age
|
• in the fetal liver and bone marrow
|
growth/size/body
• by 2 weeks of age
|
• by 4 weeks of age
|
nervous system
skeleton
digestive/alimentary system
endocrine/exocrine glands
small testis
(
J:170216
)
• progressive
|
immune system
• by 2 weeks of age
|
cellular