Phenotypes Associated with This Genotype

Genotype
MGI:4946282

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-MYC)36Bop/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:169920 )

• mice fed a diet supplemented with DOX to stimulate transactivating function of the rtTA protein and induce MYC expression exhibit reduced lifespan

neoplasm

increased metastatic potential ( J:169920 )

• 16.7% of DOX treated mice exhibit metastases

increased lung tumor incidence ( J:169920 )

• 100% of tumors show activating Kras mutations

increased lung adenoma incidence ( J:169920 )

• mice treated with DOX develop papillary adenomas

increased lung adenocarcinoma incidence ( J:169920 )

• 23.8% penetrance of adenocarcionomas in untreated mice and 56.7% penetrance in DOX treated mice

respiratory system

increased lung tumor incidence ( J:169920 )

• 100% of tumors show activating Kras mutations

increased lung adenoma incidence ( J:169920 )

• mice treated with DOX develop papillary adenomas

increased lung adenocarcinoma incidence ( J:169920 )

• 23.8% penetrance of adenocarcionomas in untreated mice and 56.7% penetrance in DOX treated mice