Phenotypes Associated with This Genotype

Genotype
MGI:4946273

• Allelic Composition: Tg(Mx1-cre)1Cgn/0; Thoc5^tm1Tate/Thoc5^tm1Tate
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:169944 )

• mice die within 2 weeks of pIpC treatment

• however, transplantation with wild-type bone marrow rescues lethality

hematopoietic system

decreased common myeloid progenitor cell number ( J:169944 )

• pIpC-treated mice exhibit reduced GM- and GEMM-CFUs compared with control mice

abnormal lymphopoiesis ( J:169944 )

• pIpC-treated mice exhibit spots of proliferating lymphoid cells unlike in control mice

anemia ( J:169944 )

• in pIpC-treated mice

decreased bone marrow cell number ( J:169944 )

• in pIpC-treated mice

decreased erythrocyte cell number ( J:169944 )

• in pIpC-treated mice

decreased hematocrit ( J:169944 )

• in pIpC-treated mice

decreased hemoglobin content ( J:169944 )

• in pIpC-treated mice

thrombocytopenia ( J:169944 )

• in pIpC-treated mice

decreased leukocyte cell number ( J:169944 )

• in pIpC-treated mice

decreased hematopoietic stem cell number ( J:169944 )

• pIpC-treated mice exhibit reduced Lin-Sca-Kit+ cells compared with control mice

decreased spleen weight ( J:169944 )

• in pIpC-treated mice

abnormal bone marrow cell physiology ( J:169944 )

• pIpC-treated mice exhibit increased leukocyte apoptosis in bone marrow unlike control mice

liver/biliary system

pale liver ( J:169944 )

• in pIpC-treated mice

immune system

abnormal lymphopoiesis ( J:169944 )

• pIpC-treated mice exhibit spots of proliferating lymphoid cells unlike in control mice

decreased leukocyte cell number ( J:169944 )

• in pIpC-treated mice

decreased spleen weight ( J:169944 )

• in pIpC-treated mice