Analysis Tools
renal/urinary system
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• decreased renal injury after bilateral renal ischemia reperfusion (I/R)
• reduced histopathologic changes in the corticomedullary region, such as tubular necrosis, dilation, and loss of brush border
• 24 hrs after bilateral renal I/R injury, the increase in serum urea and creatinine levels is significantly prevented
• renal function is improved by approximately 50% compared with wild-type mice
• renal function is fully restored after 14 d, whereas renal function of the wild type is still impaired
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immune system
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• modestly increased bacterial load in peritoneal lavage fluid at 6 h after infection during E. coli peritonitis, compared to wild-type mice
• similar bacterial load in peritoneal lavage fluid 20 h after infection or in other body compartments
• no differences in the number of neutrophils or macrophages in the peritoneal cavity
• no effect in the severity of organ injury induced by abdominal sepsis
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• increased monocyte chemoattractant protein 2 (MCP-2) level in plasma at 6 h after infection during E. coli peritonitis
• decreased MCP-1 concentrations in plasma at 20 h after infection during E. coli peritonitis
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• decreased TNF-alpha concentrations in plasma at 20 h after infection during E. coli peritonitis
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• enhanced peritoneal MCP-2, keratinocyte-derived cytokine, and LPS-induced CXC chemokine release at 6 h after infection during E. coli peritonitis
• trend towards enhanced peritoneal MCP-1 release at 20 h after infection during E. coli peritonitis
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• trend towards enhanced peritoneal IL-1beta release at 20 h after infection during E. coli peritonitis
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• trend towards enhanced peritoneal IL-10 release at 20 h after infection during E. coli peritonitis
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• enhanced peritoneal IL-6 release at 20 h after infection during E. coli peritonitis
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• enhanced peritoneal TNF-alpha release at 20 h after infection during E. coli peritonitis
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• reduced influx of neutrophils and macrophage into the postischemic kidney 1 d after I/R
• similar total leukocyte, neutrophil, lymphocyte or monocyte counts in peripheral blood
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cardiovascular system
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• absence of cellular ruffling and an irregular surface punctuated by retracted cells and/or very thin or flattened endothelial cells in the vessels invading subcutaneous Matrigel implants
• few pinocytotic vesicle in the microvessels
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• reduced (20%) density of vessels at the edge of the wounds on day 3
• similar leukocyte recruitment compared with wild type
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• reduced vessel densities of tumors compared to that of tumors in wild-type animals after subcutaneous injection of the B16 melanoma line and an ovarian tumor line
• similar leukocyte recruitment compared with wild type
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• reduced vascularization around and within subcutaneously implanted Matrigel plugs containing B16 tumor cells
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• decreased ability of the mutant endothelial cells to form tubular networks on Matrigel in vitro
• normal hyaluronan adhesion, proliferation, migration, and susceptibility to apoptotic stress in endothelial cells
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neoplasm
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• reduced (>70%) weight of both tumors compared to that of tumors in wild-type animals after subcutaneous injection of the B16 melanoma line and an ovarian tumor line
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nervous system
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• severe impairment of excitatory synaptic transmission in preBotC neurons
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• moderately increased amplitude of glutamatergic mEPSCs in preBotC neurons
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• decreased frequency of glutamatergic mEPSCs in preBotC neurons
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digestive/alimentary system
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• modestly increased bacterial load in peritoneal lavage fluid at 6 h after infection during E. coli peritonitis, compared to wild-type mice
• similar bacterial load in peritoneal lavage fluid 20 h after infection or in other body compartments
• no differences in the number of neutrophils or macrophages in the peritoneal cavity
• no effect in the severity of organ injury induced by abdominal sepsis
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homeostasis/metabolism
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• twenty-four hours after bilateral renal I/R injury, the increase in serum creatinine levels is significantly prevented
• renal function is improved by approximately 50% compared with wild-type mice
• renal function is fully restored after 14 d, whereas renal function of the wild type is still impaired
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• increased monocyte chemoattractant protein 2 (MCP-2) level in plasma at 6 h after infection during E. coli peritonitis
• decreased MCP-1 concentrations in plasma at 20 h after infection during E. coli peritonitis
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• decreased TNF-alpha concentrations in plasma at 20 h after infection during E. coli peritonitis
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• twenty-four hours after bilateral renal I/R injury, the increase in serum urea levels is significantly prevented
• renal function is improved by approximately 50% compared with wild-type mice
• renal function is fully restored after 14 d, whereas renal function of the wild type is still impaired
|
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• decreased renal injury after bilateral renal ischemia reperfusion (I/R)
• reduced histopathologic changes in the corticomedullary region, such as tubular necrosis, dilation, and loss of brush border
• 24 hrs after bilateral renal I/R injury, the increase in serum urea and creatinine levels is significantly prevented
• renal function is improved by approximately 50% compared with wild-type mice
• renal function is fully restored after 14 d, whereas renal function of the wild type is still impaired
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• delayed wound closure during days 1 to 3 after wounding
• by day 7 have recovered and is similar to that of wild-type animals
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