Phenotypes for Cd44 Tg(MMTV-PyVT)634Mul MGI:4943925 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (74 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased metastatic potential ( J:100774 )

• an increase in the percentage of mice developing metastases at 14 weeks, compared with Cd44^tm1Mak/+, Tg(MMTV-PyVT)634Mul mice

• a greater number of metastases per lung

• similar tumor onset or size in breast

• similar hyaluronan deposition in the pulmonary metastases

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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